Abstract

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Morse, P.F.; Horrobin, D.F.; Manku, M.S.; Stewart, J.C.; Allen, R.; Littlewood, S.; Wright, S.; Burton, J.; Gould, D.J.; Holt, P.J.; Jansen, C.T.; Matila, L.; Meigel, W.; Dettke, T.H.; Wexler, D.; Guenther, L.; Bordoni, A.; Patrizi, A.
Meta-analysis of placebo-controlled studies of the efficacy of Epogam in the treatment of atopic eczema. Relationship between plasma essential fatty acid changes and clinical response
Br J Dermatol 1989; 121(1): 75-90.

Abstract
Gamma-linolenic acid in the form of a particular variety of evening primrose oil (Epogam) has been reported of value in the treatment of atopic eczema. Nine controlled trials of evening primrose oil were performed in eight centres. Four of the trials were parallel and five cross-over. Doctors and patients assessed the severity of eczema by scoring measures of inflammation, dryness, scaliness, pruritus and overall skin involvement. Individual symptom scores were combined to give a single global score at each assessment point. In the analysis of the parallel studies, both patient and doctor scores showed a highly significant improvement over baseline (P less than 0.0001) due to

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